|
KMID : 1036020130020010019
|
|
지질.동맥경화학회지
2013 Volume.2 No. 1 p.19 ~ p.26
|
|
|
Effect of Fenofibrate Therapy on Blood Creatinine Levels in Patients with Hypertension and Hypertriglyceridemia
|
|
Cho Jun-Hwan
Choi Young-Hwan
Hyeok Cheol-Won
Kim Kyung-Joon
Hyeon Seong-Hyup
Kwon Jee-Eun
Kim Eun-Young
Lee Wang-Soo
Lee Kwang-Je
Kim Sang-Wook
Kim Tae-Ho
Kim Chee-Jeong
|
|
|
Abstract
|
|
|
Objective: Previous studies have reported that fenofibrate therapy increased blood creatinine levels. We investigated the effect of fenofibrate therapy on creatinine levels in patients with hypertension and hypertriglyceridemia.
Methods: This retrospective study included 36 hypertensive patients with hypertriglyceridemia taking fenofibrate for 1-3 years (Fenofibrate group) and 36 control patients with similar age, sex, follow-up duration, creatinine levels, and lipid levels to those of fenofibrate therapy (Control group).
Results: Baseline parameters except lipid profiles were similar between the fenofibrate and control groups. Creatinine levels increased in the fenofibrate group (from 0.90±0.18 mg/dL to 1.05±0.22 mg/dL, p<0.001) and did not change in the control group (from 0.91±0.12 mg/dL to 0.92±0.14 mg/dL, p=0.39). The elevation was more pronounced in the fenofibrate group than in the control group (0.15±0.12 vs. 0.02±0.11 mg/dL, p<0.001). Changes in creatinine levels were only associated with fenofibrate therapy (r=0.52, p<0.001) in the stepwise linear regression analysis.
Conclusion: Fenofibrate therapy for 1-3 years significantly increased creatinine levels in hypertensive patients with hypertriglyceridemia. This finding suggests that follow-up measurement of creatinine level is necessary with fenofibrate therapy.
|
|
|
KEYWORD
|
|
|
Fenofibrate, Creatinine, Hypertension, Hypertriglyceridemia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|